ABSTRACT
About half of Nigerian population experience at least one episode of malaria per year, resulting in high morbidity and mortality and loss of economic value. Retrospective study of the profile of malarial patients and the antimalarial drugs prescribed at Umaru Musa Yaradua memorial Hospital, Sabon-Wuse, Niger State, Nigeria were undertaken. The Plasmodium species among the malarial patients were also studied. The susceptibility of the predominant species to the prescribed antimalarial drugs was investigated. PCR analysis of the DNA of the resistant Plasmodiuum species isolates against the test antimalarials were studied using Qiagen DNeasy blood and tissue kit method. The retrospective study showed that Artemisinin Combination Therapy (ACT) was the predominantly prescribed drugs while the month of May and October had the highest incidence of malarial infection in the years studied. Plasmodium falciparum (85.7%) was the predominant malaria parasite isolated from malaria patients in Sabon-Wuse, Niger State, Nigeria. Plasmodium malariae accounts for only 14.5% of the malaria parasite observed in the area. Only 5% of the P. falciparum parasites were sensitive in vitro to Chloroquine. PCR analysis of the DNA indicated the presence of Pfcrt-Ra Gene in the study area, which further confirms resistance to Chloroquine. Plasmodium falciparum isolates were observed to be sensitive in vitro to Artesunate-Amodiaquine drug in the study area. The investigation also shows that all the samples analysed had multi antimalarial drug resistant gene Pfcrt/FB (76T). A high percentage (87.5%) of the samples analysed displayed the multidrug resistant gene Pfcrt/FB (76K) at 76 bp. The result of the PCR analysis of the DNA corroborates the observed in vitro susceptibility studies. Thus, there is the need for periodic antimalarial surveillance in order to curb emergence of multi antimalarial drug resistance as observed in Sabon-Wuse.
BACKGROUND OF THE STUDY
Higher education is defined as the education that is provided following...
ABSTRACT
This research project entitled ‘Analysis Of The Application Of The Law In Relation...
Abstract
This research is an attempt to find out the attitude of students towards English Language and how it...
ABSTRACT
Information and Communication Technology (ICT) has brought unprecedented changes and transformation to academic...
ABSTRACT
The creative abilities of humans have allowed them through time to manipulate and control thei...
Abstract
This study seeks to analyze the role of mass media in crusade against terrorism especially in Nigeria with the...
ABSTRACT
This experiment was conducted to investigate the growth performance and carcass characteristics of weaner rabbits fed varying le...
ABSTRACT
This study is on “Influence of Supervision on Provision and Management of Resources in Secondary Schools in Kano Metropoli...
ABSTRACT
This work seeks to examine the relationship between the Ubulus in Aniocha and the various Ubulu Communities in...
ABSTRACT
There is the global recognition of the importance of expectations in the conduct of monetary policy, which...